DEMENTIA: 8 Facts About Lewy Body Dementia

DEMENTIA: 8 Facts About Lewy Body Dementia

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Lewy body dementia, the second most common type of progressive dementia after Alzheimer’s disease, causes a progressive decline in mental abilities. LBD is a condition similar to Alzheimer’s disease but is a separate disease entirely. While both diseases cause loss of memory, the microscopic findings in brain tissue from LBD patients are different from those in people with AD. The important distinction is that in LBD there are small “Lewy bodies” inside the brain’s cells.  These Lewy bodies are neither plaques nor tangles, but rather synuclein, the same protein found in brains of people with Parkinson’s disease. 

Here are 8 Facts about Lewy Body Dementia you should know: 

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It affects millions: At last count, somewhere around 1.3 million Americans are affected by LBD, the second most common form of dementia (behind Alzheimer’s disease).

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It’s not Alzheimer’s: One of the typical misconceptions about dementia is that it can be used interchangeably to describe Alzheimer’s disease. However, Alzheimer’s is but one form of dementia, the term used to describe an impaired mental state that is caused or accompanied by any of the following: impaired memory, issues with decision making, trouble with problem solving and difficulty when trying to learn new skills. There are crucial differences between dementia that is caused by Alzheimer’s disease and LBD. For one thing, people with LBD experience unpredictable changes in their cognition, regardless of the time of day, whereas people with Alzheimer’s tend to have more trouble when the sun goes down—a symptom referred to as “sundowning.” Those with LBD also tend to have more hallucinations and movement issues, whereas the hallmarks of Alzheimer’s are memory loss and trouble performing familiar tasks.

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 It’s difficult to diagnose: As with Alzheimer’s, LBD can only be conclusively diagnosed by doing a biopsy on an individual’s brain after they have died. When diagnosing living patients, doctors consider the person’s symptoms, interview their family members, perform physical and mental evaluations, and conduct blood tests and brain imaging tests (MRI, CT). The main symptom of LBD is, of course, dementia. Other symptoms of LBD include: problems with depth perception, hallucinations (often visual), delusions, paranoia, Parkinsonism (body stiffness, tremors, trouble walking) and physical issues (such as heart rate and blood pressure fluctuations, constipation, fainting spells). To be diagnosed with LBD, an individual must have dementia and several of the aforementioned symptoms.

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It can affect medications: An accurate, timely diagnosis of LBD is essential to avoiding dangerous medication reactions. Many drugs prescribed to people with Alzheimer’s disease and Parkinson’s disease—especially anti-psychotics—can have a dangerous effect on people with LBD. Neuroleptic Malignant Syndrome is a neurological disorder brought on by a negative reaction to neuroleptic or anti-psychotic medications that often occurs in people with LBD. Individuals who develop Neuroleptic Malignant Syndrome can experience muscular rigidity, high fever, variable blood pressure and severe sweating.

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It’s similar to Parkinson’s: People with LBD often exhibit the same symptoms as those with Parkinson’s disease dementia (PDD). While the two conditions start off differently, their biological underpinnings are closely related, and people with Parkinson’s can be diagnosed with either condition. The primary factor physicians use to distinguish between these two dementias is when the cognitive symptoms first began. People who start to develop dementia within a year of their Parkinson’s diagnosis are thought to have LBD, while those whose dementia symptoms start later are thought to have PDD.

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It can impact sleep: Sleep issues and dementia tend to go hand-in-hand, but there’s a specific sleep condition that appears to affect a large number of people with LBD. Studies indicate that as many as two-thirds of LBD patients grapple with REM Sleep Behavior Disorder (RBD), marked by movement, speaking and gesturing during the REM (rapid-eye-movement) stage of sleep.

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It’s unpredictable: One of the biggest challenges facing those with LBD and their families is the fact that symptoms of the disease tend to wax and wane erratically. Periods of mental fog, aggressive behavior, movement issues, and vivid hallucinations can last seconds, minutes, hours or days. Because of this, it can be nearly impossible to determine where a person is in the progression of the disease. Sometimes, the fluctuations in symptoms can be caused by underlying infections or medications. Once the causal factor has been remedied, the person with LBD often returns to the level of functioning they were experiencing before the unexpected decline. But not all increases in symptoms can be traced to an outside source, such is the variable nature of the disease.

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It has no cure: There is currently no way to cure or halt the progression of LBD. Those who’ve been diagnosed with the condition may be prescribed drugs to deal with certain symptoms. For instance, cognitive issues may be addressed with cholinesterase inhibitors, a type of medication that promotes brain cell function by affecting the neurotransmitter acetylcholine. For those with RBD, treatment with clonazepam or melatonin might be effective. And levodopa may be used to mitigate the effects of severe Parkinsonism. Occupational, speech and physical therapy are the most common non-pharmaceutical approaches to helping people with LBD manage their condition and function better in their day-to-day life.

January 20, 15 (

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